ITGA4 and arthrogryposis: Among the 12 PPI sub-networks identified using these genes as input in Metaboanalyst, only one sub-network comprising ITGAV, NCKAP1, and ITGA4 appeared to be involved in the regulation of actin cytoskeleton (with experimental evidence and high confidence score), which is relevant to arthrogryposis development [24] (Fig. 2).