In the acute phase, downregulation of Gpr88, which is implicated in spatial learning and anxiety [49, 50], was specific to Nrip3+ interneurons in the frontal cortex; Tfrc, which modulates ferroptosis sensitivity [51]—a mechanism of cell death, was downregulated in endothelial cells in the hippocampus and frontal cortex; Mrps6, which was specifically upregulated in astrocytes in both the cortex and the hippocampus, has been linked to PD [52]. This evidence concerns the gene GPR88 and Anxiety.