Univariate analysis of the Cox proportional hazards model revealed that the factors significantly associated with PFS were TNM stage, distant metastasis, line of systematic therapy, FAP expression, and CD8 + T cell density, whereas age, gender, histology, ECOG PS, type of immunotherapy, stroma fraction, and CD3 + T cell density were not associated with the PFS of advanced NSCLC patients (Fig. 5b and Supplementary Fig. 2a–e). The gene discussed is CD8A; the disease is non-small cell lung carcinoma.