CD8A and vitiligo: Xu et al[1] recently identified subsets of dermal fibroblasts that are responsible for driving patterned autoimmune activity, by using a robust mouse model of vitiligo that is based on the activation of endogenous auto-reactive CD8+ T cells that target epidermal melanocytes.[1] Using advanced, powerful single-cell and imaging techniques, this study demonstrated the feedforward system between CD8+ T cells and skin fibroblasts which is of prime importance in the progression of vitiligo.[1]