IFNG and vitiligo: The transcriptional signatures of the skin fibroblasts vary across the limbs, diverging from the torso toward the fingers or toes, suggesting that fibroblasts are imprinted with positional identity.[4] Such imprinting occurs during development and is maintained in the postnatal period by epigenetic regulation of HOX genes.[5] In this study, the regional variation of fibroblast responses to IFNγ was proven to be associated with the skin lesion distribution in nonsegmental vitiligo.