TIMP1 and metabolic dysfunction-associated steatohepatitis: Only hepatic mRNA expression of TIMP1 was obviously increased in MCD plus α-GalCer-treated mice compared to control mice (36.7 vs. 14.9, p = .005) (Figure 5(B)), which suggests that NKT cell anergy or tolerance induced by chronic α-GalCer administration contributes to the profibrogenic molecular response in MCD-induced NASH.