Among the four main clinical categories, Alzheimer's disease (AD), Frontotemporal lobe dementia (FTLD), vascular dementia (SVD), dementia with Lewy Bodies (Pilotto et al., 2021) and minimal cognitive deficit (MCI), Nf concentrations were consistently found to be highest in FTLD (Petzold et al., 2007; Ende et al., 2019). This evidence concerns the gene NFASC and snowflake vitreoretinal degeneration.