In line with this, western blot analysis showed significant downregulation of Bcl-2 (p = 0.0006 versus ND-IHD; Figures 1C and S1B), while apoptotic marker cleaved caspase-3 was upregulated (p = 0.040 versus ND-IHD; Figures 1D and S1D). Here, CASP3 is linked to myocardial ischemia.