GJ-4 treatment could markedly decrease the mRNA expression of TNF-α and IL-1β, while the levels of TGF-β and IL-4 mRNA were increased by treatment with GJ-4 in VD rats (Fig. 6a–d), indicating that GJ-4 could inhibit microglial M1 polarization and promote M2 polarization. The gene discussed is IL1B; the disease is sexually transmitted disease.