LATE was found in all cases and is commonly seen in association with Alzheimer’s disease neuropathologic change,31 Lewy body pathology,47 small vessel disease48 and ageing.41 Case 6 displayed hallmark pathological features of frontotemporal lobar degeneration with tau inclusions, specifically corticobasal degeneration. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.