In particular, patients with pathological GS 4 + 4 and GS 5 + 3 tumours were at a higher risk of BCR than patients with pathological GS 3 + 5 tumours (hazard ratio 4.54, P = 0.03 and hazard ratio 11.2, P = 0.01, respectively). The gene discussed is BCR; the disease is neoplasm.