Studies have reported some AD-associated lncRNAs, such as BACE1-AS, 51A, BDNF-AS and NAT-Rad18 that are aberrantly expressed in late-onset Alzheimer's disease (LOAD) compared with healthy controls (Abdolmaleki et al., 2021[1]; Cortini et al., 2019[6]). The gene discussed is BACE1; the disease is early-onset autosomal dominant Alzheimer disease.