The most commonly analyzed ACE2 polymorphism in the context of COVID-19 severity is rs2285666, which is proposed to affect splicing of the primary transcript (Karakaş Çelik et al., 2021[26]; Gómez et al., 2020[20]; Möhlendick et al., 2021[34]; Novelli et al., 2020[36]; Pouladi et al., 2021[40]). The gene discussed is ACE2; the disease is COVID-19.