Thrombocytopenia in sepsis can be explained by various mechanisms such as complement activation; increased markers of coagulation activation such as thrombin release; hemophagocytosis; a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) depletion; and release of histones. Here, ADAMTS13 is linked to Sepsis.