Other treatments include cyclosporine, cyclophosphamide, vincristine, N-acetylcysteine, and splenectomy, which can reduce the rate of relapse in patients with recurrent TTP. Emerging therapies include caplacizumab, a novel anti-von Willebrand factor nanobody, and recombinant ADAMTS13 [18]. The gene discussed is ADAMTS13; the disease is thrombotic thrombocytopenic purpura.