If rapid ADAMTS13 testing is not possible, the platelet count; combined hemoLysis variable; absence of active cancer; absence of stem-cell or solid-organ transplant; mean corpuscular volume (MCV); INR; creatinine (PLASMIC) score, a seven-component prediction tool that can accurately and reliably predict the probability of severe ADAMTS13 deficiency, can be used [19]. The gene discussed is ADAMTS13; the disease is cancer.