MUC5AC and systemic inflammatory response syndrome: The most common causes of DIC are severe sepsis, usually with septic shock; disseminated malignancy, most classically with mucin-secreting pancreatic adenocarcinoma; pregnancy with various severe complications, including sepsis, placental abruption, and eclampsia; cases of life-threatening illnesses characterized by systemic inflammatory response syndrome (SIRS) with hypotension and multiorgan dysfunction.