IGF1 and overgrowth syndrome: These children exhibit partial IGF-1 resistance associated with relatively high IGF-1 and IGFBP-3 levels.35 The typical features include prenatal and postnatal growth failure, underweight, relative macrocephaly, triangular face, body asymmetry, and several minor anomalies such as clinodactyly V.36,37 Conversely, among imprinting disorders, the most common overgrowth syndrome is represented by Beckwith–Wiedemann syndrome.