LPL and COVID-19: The NIH COVID-19 Treatment Guidelines Panel recommends the use of heparinoids in hospitalized patients with COVID-19 for prophylactic purposes.51 Recent studies and data suggest that physicians should be aware that low-molecular-weight heparin in patients with thyroid-related diseases may disrupt thyroid function and affect laboratory findings.72 Heparin enhances endothelial lipoprotein lipase activation and increases serum non-esterified fatty acid (NEFA) concentration.