Many of the day-to-day benefits of using CGM and FLASH systems can be related to the simple on-demand features that provide more frequent, painless insights into current glucose levels that accompany each scan of the glucose sensor, along with the glucose trend arrows that indicate the direction and rate of change in glucose levels.13,14 These allow users with T1DM or T2DM to understand their glucose fluctuations and make appropriate decisions on food consumption and insulin dosing, with consequent improvements in treatment satisfaction and reduced burden of diabetes. This evidence concerns the gene INS and type 1 diabetes mellitus.