It is approved as an adjunct to a reduced-calorie diet and increased physical activity in people with obesity or overweight and at least one weight-related comorbidity, including dysglycaemia (prediabetes or T2D), hypertension, dyslipidaemia, OSAS or CVD.42 Like liraglutide, semaglutide belongs to the GLP-1 RAs class of drugs. Here, GLP1R is linked to obesity due to melanocortin 4 receptor deficiency.