GIP positively impacts energy storage by controlling fat metabolism and lipid storage through increased blood flow in adipose tissue and triglyceride uptake; it also accumulates fat via the CNS in humans (Figure 1).36,37 GIP plays an important role in the regulation of food intake, lipoprotein lipase activity and fat decomposition during carbohydrate/fat degradation in adipose tissue; it produces a direct lipolytic effect during hyperglycaemia and low levels of insulin.38 This evidence concerns the gene INS and Hyperglycemia.