6-Gingerol improves hypertension biomarkers expression and reduces lipid accumulation by increasing phosphorylated endothelial nitric oxide synthase (eNOS) protein, vascular cell adhesion protein 1 (VCAM1), TNFα, epithelial sodium channel (ENaC) protein through PPARδ in mouse preadipocytes (3T3-L1 cells), human embryonal kidney cells (HEK293 cells), and human umbilical vein endothelial cells (HUVECs) (105). This evidence concerns the gene NOS3 and Hypertension.