HOTAIR modulates KLF12 to regulate GC progression via the PI3K/ATK signaling pathway by sponging miR-618 (42). It has been reported that lncRNAs such as H19, HOTAIR, UCA1, and PVT1 could serve as potential diagnostic and prognostic biomarkers in patients with GC (43). The gene discussed is PVT1; the disease is gastric cancer.