Potential SPL markers [such as sphinganine-1-phosphate, Cer(d18:1/18:1), Cer(d18:1/24:1), and Cer(d18:1/16:0)-1P] have been reported that differ from those associated with liver disease (Cartier and Hla 2019; Jia et al. 2019; McGinley and Cohen 2021; Parveen et al. 2019). This evidence concerns the gene CBLN1 and liver disorder.