Multiple linear regression analysis was performed with the factors, and age (β = 0.266, p = 0.001), IGF-1 (β = − 0.164, p = 0.033), osteoporosis (β = − 0.273, p = 0.001), and osteoarthritis (β = − 0.302, p < 0.001) were found to be significantly associated with the Locomo-25 score. This evidence concerns the gene IGF1 and osteoporosis.