We used datasets available from online resources to analyse the frequency of genetic alterations occurring in KPNA2 mRNA expression levels across breast cancer intrinsic molecular subtypes (Geneminer, cBioPortal, COSMIC and Oncomine), examined patterns of KPNA2 co-expression with other genes (Geneminer and Oncomine) and evaluated the prognostic implications of KPNA2 mRNA overexpression in patients with breast cancer (Prognoscan and Kaplan–Meier Plotter). The gene discussed is KPNA2; the disease is breast carcinoma.