Baseline data from a randomized controlled trial, in which premenopausal women with intraepithelial neoplasia or micro-invasive breast cancer were compared to healthy high-risk women (5-year Gail score > 1.3%), showed a decrease in risk with increasing adiponectin (but not leptin) concentrations [50]. The gene discussed is ADIPOQ; the disease is intraepithelial neoplasia.