In this work, we examined associations between seven serum biomarkers of inflammation (interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 10 (IL-10), tumor necrosis factor α (TNF-α), interferon γ (IFN-γ) and adipokines (leptin and adiponectin) and breast cancer risk in premenopausal women from Latin America, using data from the multicentric PRECAMA population-based case–control study. This evidence concerns the gene CXCL8 and breast cancer.