Herein, we found that FTO was the only gene associated with two different traits: obesity [48••, 49] and blood pressure [50], and interacting with four different environmental factors: physical activity [48••, 49], smoking habit [48••], sweet beverage [48••] and alcohol consumption [50] (Supplementary Tables 2 and 4). Here, FTO is linked to obesity due to melanocortin 4 receptor deficiency.