Previously published research did not confirm the presence of an association between the HMGA1 protein expression in lung cancer tissue and age, gender, or smoking status of enrolled patients (Zhang et al. 2015, 2019; Lin and Peng 2016) expect the research of Lin and Peng (2016) who observed the tissue HMGA1 expression more frequently in males than females. The gene discussed is HMGA1; the disease is lung cancer.