The global brain development transcription factor (BRN2) levels were also decreased in the organoid study, and transcription factor GS Homebox 1, (GSX1) which patterns ventral-telencephalic patterning was also affected as well as markers related to interneuron development, which as discussed is related to schizophrenia and other mental illness [140, 142]. Here, POU3F2 is linked to schizophrenia.