One-year OS was associated with ECOG PS (HR 0.181, 95% CI 0.119–0.276, P < 0.001), EGFR mutation (HR 2.171, 95% CI 1.006–4.684, P = 0.048), and pleural effusion (HR 0.634, 95% CI 0.430–0.935, P = 0.021) (Table 3). Here, EGFR is linked to Pleural effusion.