EGFR and Pleural effusion: ECOG PS (HR 0.164, 95% CI 0.098–0.275, P < 0.001), EGFR mutation (HR 2.664, 95% CI 1.348–5.262, P = 0.005), pleural effusion (HR 0.497, 95% CI 0.356–0.695, P < 0.001) and EML (HR 0.630, 95% CI 0.441–0.899, P = 0.011) were associated with 1-year PFS.