FGFR2 and neoplasm: We observed an overall upregulation of Fgfr2 transcripts in tumours with SB insertions (Extended Data Fig. 1e), suggesting a loss of regulatory elements that are presumably encoded by the Fgfr2 3′-untranslated region (3′-UTR)21 and/or positive oncogenic selection of C-terminally truncated FGFR2.