MMP1 and neoplasm: Tumor-bearing status (HR = 3.594, 95%CI = 1.429–9.036, P = 0.007) and MMP1 expression (HR = 1.524, 95%CI = 1.238–1.875, P < 0.001) were independent factors associated with poor OS, while the age > 60 (HR = 0.501, 95%CI = 0.268–0.939, P = 0.031) and R1&2 resection (HR = 0.226, 95%CI = 0.073–0.701, P = 0.010) were independent protective factors.