According to the reported studies so far, most inferential mechanisms and pathways based on experiments revealed that up-regulation of MMP1 expression led to tumor progression, involving the down-expression of circ DLC158, capicua (CIC)59 and MTAP60, and the up-expression of 14–3-3σ61, MPP362 and c-Jun63. The gene discussed is MMP1; the disease is neoplasm.