We proceeded to conduct Wilcoxon signed rank test on 50 matched pairs sample in TGCA (Fig. 3B) and included data of the normal tissues from the GTEx database as controls (corrected the batch effects via TOIL method) to further evaluate the difference in MMP1 expression between tumor and normal tissues of LIHC (Fig. 3C). This evidence concerns the gene MMP1 and neoplasm.