F2 and neoplasm: T3&T4 stage (P < 0.001), M1 stage (P = 0.017), pathologic stage III&IV (P < 0.001), tumor-bearing status (P < 0.001), MMP1 expression (P < 0.001) were significantly correlated with OS (Table 4), T3&T4 stage (P < 0.001), M1 stage (P = 0.024), pathologic stage III&IV (P < 0.001), prothrombin time > 4 (P = 0.031), Child–Pugh B (P = 0.047) and MMP1 expression (P < 0.001) to DSS (Table 5) and T3&T4 stage (P < 0.001), M1 stage (P = 0.035), pathologic stage III&IV (P < 0.001), tumor-bearing status (P < 0.001), vascular invasion (P = 0.003) and MMP1 expression (P < 0.001) to PFI (Table 6).