Therefore, after in situ treatment with AdRGD-PG-p19 and AdRGD-PG-IFNβ gene therapy, MCA tumors were injected (i.t) with 10 mg/kg of Dox, which when used individually does not reduce tumor progression to the same extent as the dose of 20 mg/kg (Fig. 6a). Here, IFNB1 is linked to neoplasm.