AKT1 and Parkinson disease: In the pathways that significantly overlapped with downregulated genes, we found several metabolic pathways and pathways related to protein folding, as well as a few pathways that were not known before to relate to PD and are common in many of our mutation lines as well as sPD (as will be presented in the subsequent figures), such as extracellular matrix pathways (probably the most dysregulated pathways), and PI3K-Akt signaling pathways, lysosome membrane degradation, and focal adhesion.