NCKIPSD and neoplasm: In our previous work, we revealed that SPIN90 (SH3 protein interacting with Nck, 90 kDa) [21] is significantly decreased in the tumor stroma of breast cancer patients and that SPIN90-knockout (KO) mouse embryonic fibroblasts (MEFs) showed a more myofibroblastic CAF phenotype than wild-type MEFs [22].