Kaplan–Meier (KM; https://kmplot.com/analysis/; Affymetrix ID: 216116) analysis revealed that a lower SPIN90 level in tumor tissues is associated with shorter survival rates in ER-positive patients (n = 2354), not in ER-negative patients (n = 1080) (Fig. 1A). The gene discussed is ESR1; the disease is neoplasm.