ACTA1 and neoplasm: To determine the CAF activation ability of miR-130b-3p in vivo, MCF7 cells expressing a nonspecific oligonucleotide (MCF7 NC-i) or a specific inhibitor sequence of miR-130b-3p (MCF7 130b-i) were injected into the mammary fat pads of mice, and the expression levels of α-SMA and SPIN90 were assessed by IHC of serial tumor tissues.