EGFR and Insulin resistance: To investigate whether EGFR in hepatocytes mediated insulin resistance resulting from the HFD, we generated mice with selective EGFR deletion in hepatocytes (Alb1-Cre; EGFRf/f, hepatocyte EGFR−/−) and corresponding WT (EGFRf/f) mice and fed them the HFD for 12 weeks.