Mixed/ALS-MP, PD-MP, and CBS-MP signs occurred earliest in c9orf72 pathogenic variant carriers, in agreement with the early detectable structural imaging findings17,47 and slow progress described in some c9orf72 patients.48, -, 50 In contrast, in MAPT pathogenic variant carriers that have been typically described in association with motor disorders, motor signs occurred later. This evidence concerns the gene MAPT and amyotrophic lateral sclerosis.