Recent studies have demonstrated a similar widespread pattern of subtle bilateral cortical thinning involving frontal, parietal, temporal, and occipital lobes and extensive white matter damage already in early PD.41, -, 43 However, our cases carry FTD pathogenic variants associated with TDP-43 and tau-pathology, not alpha-synucleinopathy. This evidence concerns the gene TARDBP and Parkinson disease.