INS and type 2 diabetes mellitus: Subsequent figures show gene expression in relation to glycemic status and related phenotypes such as T2D, glucose tolerance defined by HbA1c strata (normal glucose tolerance, NGT: HbA1c <6%, impaired glucose tolerance, IGT: HbA1c between 6% and 6.5%, and T2D: HbA1c > 6.5%), HbA1c as a linear variable as well as BMI, and glucose-stimulated insulin secretion (GSIS) in islets (stimulatory index, SI).