HDAC1 and cancer: Benzamide-based HDACi have a well-known capacityto induce apoptosisin cancer cells and have been tested in a range of tumor types.17 The functionalization of CI-994 into an HDAC1/2and 3 degrader, using a standard VHL ligand (JPS014 and JPS016), improvedits ability to induce cell death in HCT116 cells (Figure 3A).