In one study, CD30 gene expression was detected in all PTCL-NOS and AITL samples, with moderately strong correlation between RNA levels and CD30 expression by IHC.20 In the DLBCL cohorts of SGN35-012, baseline CD30 mRNA levels were not predictive of response to BV.19 While these findings are scientifically interesting, these investigational more sensitive methods for detecting CD30 expression lack standardization and are not widely available. This evidence concerns the gene TNFRSF8 and angioimmunoblastic T-cell lymphoma.