TNFRSF8 and neoplasm: The protein can be cleaved, resulting in shedding of the ectodomain and soluble CD30 in the blood.22-24 Multiple studies have shown elevated levels of soluble CD30 in inflammatory and oncology settings and levels may be associated with the extent of tumor burden in some malignancies.25,26 CD30 partitioning between a surface-bound and secreted form may occur in tumors and implies that CD30 surface levels are not stagnant, which could confound CD30 surface evaluation when observed at only one moment in time.