It has been previously shown that long-term OE of the inflammation-related pathway Ink4/Arf locus, comprising Cdkn2a-Cdkn2b genes that encode four potent tumor suppressors, namely p16Ink4a, p19Arfand, p15Ink4b, and p21Cdkn1a, inhibited the efficiency of in vitro reprogramming (Dulic et al., 2000; Hong et al., 2009; Li et al., 2009). Here, CDKN2A is linked to neoplasm.