SPN and Dravet syndrome: T21 is known to cause excess production of CD43+ hematopoietic progenitor cells, leading to the excess production of megakaryocyte-erythroid progenitor cells (Chiang et al., 2018; Roy et al., 2012; Tunstall-Pedoe et al., 2008), and Chiang et al. (2018) affirmed that transcriptional silencing of chr21 corrected hematopoietic pathogenesis for this known DS cellular phenotype.