Some of the candidate genes implicated were studied in mice, although single-gene perturbations did not explain all of the angiogenic phenotypes in Ts65Dn mice; overexpression of RCAN1 and DYRK1A were reported to affect proliferation, vascular structures, and tumor allografts (Baek et al., 2009; Minami et al., 2004). The gene discussed is DYRK1A; the disease is neoplasm.