The elicitation of potent serum cross-neutralizing responses in rhesus macaques by S-protein immunization is in stark contrast to human SARS-CoV-2 natural infection, which typically results in autologous nAb responses; cross-neutralizing activity against SARS-CoV-1 has been shown to be relatively rare in SARS-CoV-2 infection or vaccination (Fig. 1E and fig. The gene discussed is PROS1; the disease is infection.