APC and adenoma: Heterozygotes conditionally floxed for deletion of exons 1 to 15 in Apc (Apc+/Δex1–15), a model prone to adenoma development (19), were crossed with conditionally floxed homozygous Bmal1fl/fl mice, where the basic helix-loop-helix (bHLH) domain in exon 8 is deleted (54).