RAC1 and hepatocellular carcinoma: On HepG2, bee venom and melittin exhibit a synergistic anticancer impact with Sorafenib, suggesting a potential HCC therapeutic method [57].‏ Also, melittin inhibits tumor cell metastasis by lowering cell motility and migration via the Rac1-dependent pathway, also due to its strong anti-tumor effectiveness and improved biological safety, melittin nano-liposomes would be a good choice for HCC therapy [58].