RIMS1 and inherited retinal dystrophy: However, with the exception of one simplex case of retinitis pigmentosa (RP) found to carry heterozygous p.Arg820His RIMS1 variant,7 there are no other reports of cases with retinal dystrophy associated with this variant in RIMS1. Furthermore, no pathogenic RIMS1 variants have been seen in the next generation sequencing of a large cohort of patients with inherited retinal dystrophies performed at our institution and in the Genomics England “100,000 Genomes” dataset.8