Our investigation of the transcriptomic relationship between GCT and alcohol use identified 5 protein coding genes oppositely associated with GCT and alcohol use behavior: PLEKHM1, LRRC37A2, CRHR1, ARHGAP27, and LRRC37A. These 5 genes could contribute to the negative association between GCT and alcohol use. This evidence concerns the gene PLEKHM1 and granular cell tumor.