We identified 8 protein-coding genes associated with both GCT and 1 or more alcohol use behaviors: ACTR1B, PLEKHM1, LRRC37A2, CRHR1, ARHGAP27, WNT3, RTN1, and LRRC37A. Five of these genes, PLEKHM1, LRRC37A2, CRHR1, ARHGAP27, and LRRC37A, were oppositely associated with GCT and alcohol consumption (eTable 42 in Supplement 1). The gene discussed is PLEKHM1; the disease is granular cell tumor.