We identified 8 protein-coding genes associated with both GCT and 1 or more alcohol use behaviors: ACTR1B, PLEKHM1, LRRC37A2, CRHR1, ARHGAP27, WNT3, RTN1, and LRRC37A. Five of these genes, PLEKHM1, LRRC37A2, CRHR1, ARHGAP27, and LRRC37A, were oppositely associated with GCT and alcohol consumption (eTable 42 in Supplement 1). This evidence concerns the gene ARHGAP27 and granular cell tumor.