These data support the notion that glutamatergic transmission plays an important role in alcohol misuse.70,71 Interestingly, CRHR1 is expressed in glutamatergic, but not GABAergic, cortical neurons.72 Activation of CRHR1 in the forebrain is associated with alteration in glutamatergic neurotransmission and increased behavioral susceptibility to stress in mice.72 Therefore, our single-cell findings support our hypothesis associating cortical CRHR1 expression with increased stress susceptibility, cortical thinning, and alcohol misuse. The gene discussed is CRHR1; the disease is alcohol drinking.