The subjects with hyperuricemia tended to be older and had higher BMI and WHR, higher blood pressure, more commodities with diabetes, higher cholesterol, higher triglycerides, lower HDL-C, greater urine microalbumin and C-reactive protein, thinner ganglion cell–inner plexiform layer thickness, thinner retinal thickness, and lower IQS of OCTA imaging (all P < 0.05). Here, CRP is linked to hyperuricemia.