Given the diagnostic importance that the updated PSP criteria place on tufted astrocytes, it is uncertain if nonexperts can recognize characteristic tau-positive glial lesions (Supplementary Fig. 4, online resource) in PSP and their ability to distinguish them from astrocytic lesions in other tauopathies (Supplementary Fig. 5, online resource), including common age-related tauopathies such as AGD [27] and ARTAG [31]. The gene discussed is MAPT; the disease is tauopathy.