PAX5 and B-cell acute lymphoblastic leukemia: PAX5 is well known for its role in B cell immunity (Calderón et al., 2021; Horcher et al., 2001; Nutt et al., 1999) and its function as a haploinsufficient tumor suppressor gene in B cell acute lymphoblastic leukemia (Gu et al., 2019; Mullighan et al., 2007).