Using an H19 knockout mouse model, the authors reported a similar diabetes-like EndoMT phenotype in the retina with decreased endothelial markers CD31 and vascular endothelial (VE)-cadherin as well as increased mesenchymal markers fibroblast-specific protein 1 (FSP-1), transgelin/SM22, α-smooth muscle actin (α-SMA), and vimentin. The gene discussed is TAGLN; the disease is diabetes mellitus.