In line with this putative cardioprotective effect of H19, reduced expression of H19 has also been observed at the later stage of 3 weeks post-MI in the infarct region of a LAD ligation mouse model, whereas overexpression of H19 with lentivirus pcDNA-H19 reduced infarct size and improved cardiac function [76]. This evidence concerns the gene H19 and myocardial infarction.