ELF5 and atherosclerosis: In an attempt to study the protective effect of Icariin on atherosclerosis, it was further demonstrated that enhanced expression of H19 by Icariin inhibited EndoMT in the endothelium upon ox-LDL treatment, possibly through miR-148b-3p and its target E74-like factor 5 (ELF5) (Figure 3B).