SOD1 and Chronic colitis: In various inflammatory settings, metformin was reported to have anti-inflammatory properties beyond its effect to control glycemia.4,5,27 It increases colonic SOD and catalase activities in acute colitis28 and is beneficial in chronic colitis via improving mucosal damage score at macroscopic and microscopic levels, decreasing the oxidative stress, and the inflammatory markers.3 In a study by Yanardag et al.29 it was demonstrated that metformin increased glutathione levels in the liver of diabetic rats.